Superlative BioSciences Corporation

In Vitro Toxicological Services

Superlative BioSciences Corporation performs high-throughput in vitro assays using human cells in culture under conditions that closely mimic in vivo human tissue microenvironments.

These cell culture toxicological assays would be offered as a service-for-a-fee to companies within the pharmaceuticals, consumer goods, agricultural and cleaning products, chemicals, and medical devices industries.

1) Our first toxicological system involves the use of high-throughput in vitro biological assays in the area of developmental toxicology. 

Initial screens will involve the use of human umbilical cord-  and  placental- derived stem cells in vitro which may allow your company to  decrease the use of animals in developmental toxicology testing.  
In Vitro Developmental Toxicology Assays

The above assays will be available in high-throughput platforms that will be used to determine what adverse effects may result from exposure to a test compound (hazard identification) and at what level of exposure these effects occur (exposure/dose–response relationships).  

3D Multicellular Tumor Microenvironments
2) We are also developing human in vitro 3-dimensional multicellular systems that mimic the tumor microenvironment that may be used in the pre-clinical phase of the development of drugs, biologics, and biosimilars.

These 3-D tissue constructs, that contain multiple cell types that may be found in the tumor microenvironment, therefore will more closely represent the dynamic conditions that are exhibited in vivo in the tissues of human subjects than that which can be observed using 2-D tissue culture systems. 
3) Our 3D tissue constructs can  also be viewed using virtual reality (VR) tools. For example, using VR, detailed examinations of human melanoma by clinicians can be made, and disease progression or possible treatments determined based on these details. Patients themselves can also immerse themselves in the VR space and view the VR images using our tools. The system may also be used by pharmaceutical companies to conduct clinical trials and translate lab discoveries into real-life personal medicine applications using VR tools. See more about this technology highlighted in our 2019 Create The Future Design Contest Entry.