Superlative Biosciences LLC

In Vitro Toxicological Assays

Superlative Biosciences LLC performs high-throughput in vitro assays using human cells in culture under conditions that closely mimic in vivo human tissue microenvironments.

These cell culture toxicological assays are offered as a service-for-a-fee to companies within the pharmaceuticals, consumer goods, agricultural and cleaning products, chemicals, and medical devices industries.

1) Developmental Toxicology:

Our first toxicological system involves the use of high-throughput in vitro biological assays in the area of developmental toxicology. 

Initial screens involve the use of human umbilical cord-  and  placental- derived stem cells in vitro which may allow your company to  decrease the use of animals in developmental toxicology testing

The above developmental toxicology assays are available in high-throughput platforms that may be used to determine what adverse effects may result from exposure to a test compound (hazard identification) and at what level of exposure these effects occur (exposure/dose–response relationships). 

2) 3-D Systems That Mimic The Tumor Microenvironment:

We are also developing human in vitro 3-dimensional multicellular systems that mimic the tumor microenvironment that may be used in the pre-clinical phase of the development of drugs, biologics, and biosimilars.

These 3-D tissue constructs, that contain multiple cell types that may be found in the tumor microenvironment, therefore more closely represent the dynamic conditions that are exhibited in vivo in the tissues of human subjects than that which can be observed using 2-D tissue culture systems.